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Additional resources for Amazing Plastic Still Clever Method of Making Spirit

Sample text

8 cannot be used to infer dermal absorption of 1,2-diphenylhydrazine because the effects are inconclusive. 1 Inhalation Exposure No studies were located regarding distribution in humans or animals after inhalation exposure to 1,2-diphenylhydrazine. 2 Oral Exposure No studies were located regarding distribution in humans or animals after oral exposure to 1,2-diphenylhydrazine. 3 Dermal Exposure No studies were located regarding distribution in humans or animals after dermal exposure to 1,2-diphenylhydrazine.

The identification of unchanged 1,2-diphenylhydrazine and metabolites in the urine following oral dosing of rats with 1,2-diphenylhydrazine (Dutkiewicz and Szymanska 1973) indicates that some urinary excretion occurs. 3 Dermal Exposure No studies were located regarding excretion in humans or animals after dermal exposure to 1,2-diphenylhydrazine. 4 RELEVANCE TO PUBLIC HEALTH Death. Information regarding death in humans following exposure to 1,2-diphenylhydrazine by any route was not found. Some information is available on lethality of orally-administered 1,2diphenylhydrazine in animals.

6 INTERACTIONS WITH OTHER CHEMICALS A carcinogenicity study was reported in which groups of rats were given weekly subcutaneous injections of 1,2-diphenylhydrazine (20 mg), or 1, 2-diphenylhydrazine (20 mg) concurrently with benzidine sulfate (15 mg) for life (Genin et al. 1975). Combined incidences of tumors (injection site, liver, and other sites) were increased and the mean tumor latent period was decreased in the group with combined 1,2-diphenylhydrazine and benzidine sulfate exposure. It is unclear whether these findings provide evidence for an interaction between 1,2-diphenylhydrazine and benzidine or additive effects of two carcinogens.

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Amazing Plastic Still Clever Method of Making Spirit


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