Advances in Drug Research, Vol. 26 by Bernard Testa, Urs A. Meyer (Eds.) PDF

By Bernard Testa, Urs A. Meyer (Eds.)

ISBN-10: 0120133261

ISBN-13: 9780120133260

Quantity 26 maintains the fashion of shorter, extra common volumes. With quantity 25, the sequence won a brand new co-editor, Urs Meyer. whereas maintaining the dedication to put up chapters on healing or chemical sessions and on normal themes or options, the sequence' insurance has accelerated to incorporate methodological chapters, and new components of famous or capability value to drug study, in particular in molecular pharmacology.

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In "Advances in Drug Research", Vol. 22 (B. ), pp. 1-38. Academic Press, London. Knowles, J. P. (1991). Nature 350, 121-124. Koch, H. P. (1993). Pharmazie 48, 643-659. Koshland, D. E. (1968). Annu. Rev. Biochem. 73, 359-410. Kraut, J. (1988). Science 242, 533-540. Kuhn, L. , Siani, M. , Pigue, M. , Fisher, C. , Getzoff, E. D. and Tainer, J. A. (1992). J. Mol. Biol. 228, 13-22. Kurganov, B. I. (1993). Trends Biochem. Sci. 18, 405-406. Kurganov, B. I. and Lyubarev, A. N. (1992). J. Biochem. Org. 1, 1-7.

Interdependent properties of biomacromolecules as partial representations of complex systems. , 1992). Similarly, the grooves of DNA are characterized by a very strong electrostatic potential which attracts cations (Pullman, 1989). (3) A third reason is that a sufficient length of polypeptide is needed to enforce the shape of a protein, and particularly the precise stereoelectronic architecture of its active site. In enzymes, for example, this allows coupled vibrations and energized motions that contribute to catalytic mechanisms and an exquisitely fine-tuned stabilization of transition states (Kraut, 1988; Havsteen, 1989; Retey, 1990; Knowles, 1991; Tonge and Carey, 1992; Williams, 1993).

Eigen, 1994) 9 . 2 . Organelles, Cells, Tissues, Organs and Organisms Complex adaptative systems such as membranes are said to self-organize, but this must not be misunderstood. Indeed, self-organized criticality at each hierarchical level of biological systems is not reached independently of other levels, but in a fully coordinated and integrated manner. 1, and those to be briefly considered here appear in the title of this section. Each of the hierarchical levels in living systems can be viewed both as a system and as a subsystem; each in fact is a multilevel hierarchical system integrated with many of its kind into a higher system (Kurganov and Lyubarev, 1992; Kurganov, 1993).

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Advances in Drug Research, Vol. 26 by Bernard Testa, Urs A. Meyer (Eds.)


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