By Robert M. Julien, Claire D. Advokat, Joseph E. Comaty
Variation after variation, Robert Julien’s A Primer of Drug motion keeps velocity with probably the most dynamic fields of medical inquiry, giving scholars instant entry to the most up-tp-date examine and promising new instructions in psychopharmacology. conscientiously up to date all through, the recent version back takes its position because the definitive advisor to the medication that have an effect on the brain and behaviour. As consistently, it really is transparent, entire, aim, and authoritative, spanning a large choice of drug forms, together with sedatives, depressants, stimulants, analgesics, psychedelic medicines, steroids, and medication used to regard mental problems.
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Extra info for A Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs
By attaching to this subtype of dopamine receptor, they prevent endogenous dopamine molecules from attaching, activating, and producing an effect at these sites. Receptor Structure What does a receptor look like? Although there are several different configurations of proteins that may serve a receptor function, the following is a brief summary of the major types most relevant to the action of drugs. Ion Channel Receptors. ) The first type of membrane-spanning receptor is the kind that forms an ion channel.
Thus, increasing doses of a drug must be administered to maintain the same level of drug in the plasma and to produce the same effect produced by previously administered smaller doses. In essence, the second drug becomes less effective because it is metabolized more rapidly as a result of the increased amount of metabolic enzyme. One consequence of this development of metabolic tolerance is that any other drug that is metabolized by the same enzyme will also be broken down more rapidly. As a result, those drugs will also exert less of an effect, a phenomenon termed cross-tolerance.
It is important to remember that even though the blood level of the drug is reduced by 75 percent after two half-lives, the drug persists in the body at low levels for at least six half-lives. The so-called drug hangover is a result. Throughout this book, drug half-lives are cited to describe the duration of action of psychoactive drugs in the body and allow comparisons between drugs with similar actions but differing half-lives. Most drug half-lives are measured in hours; others are measured in days, and recovery from the drug may take a week or more.
A Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs by Robert M. Julien, Claire D. Advokat, Joseph E. Comaty