Get 2004 Pocket Book of Infectious Disease Therapy PDF

By John G. Bartlett

ISBN-10: 0781738962

ISBN-13: 9780781738965

Designed to supply easy access to the criteria with which to struggle infectious affliction through concentrating on choice, right doses, charges, and unwanted side effects of antimicrobial brokers, the 2004 notebook of Infectious disorder remedy attracts commonly from suggestions made by way of the facilities for affliction keep an eye on, the clinical Letter, the yank sanatorium Formulary provider, and the AMA's Drug reviews. Tabular fabric has been up-to-date to incorporate all newly authorized antibiotics, in addition to new options for administration.

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Extra info for 2004 Pocket Book of Infectious Disease Therapy

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Difficile colitis, hemolytic anemia, reversible ototoxicity (especially high dose and renal failure), QT prolongation with drug induced torsades de pointes especially in women (JAMA 280:1774, 1998), hypothermia, aggravation of myasthenia gravis Optic neuritis (decreased acuity, reduced color discrimination, constricted fields, scotomata—dose related and infrequent with 15 mg/kg), GI intolerance, confusion, precipitation of acute gout Hypersensitivity reactions, peripheral neuropathy, thrombocytopenia, toxic epidermal necrolysis, lichenoid skin rash Allergic reactions, peripheral neuropathy (prevented with pyridoxine), reversible liver damage (9%) with jaundice (1–3%)—monitor transaminase q2–4 wk, gynecomastia, menstrual irregularity Optic neuritis, gouty arthritis, hypothyroidism, impotence, poor diabetic control, rash, hypotension Headache, nausea, fatigue GI intolerance (bloating, nausea, vomiting, pain, anorexia, weight loss) dose related: 8–11% with 400 mg/d, 30% with >400 mg/d.

Mezlocillin: Reduce dose by 50% or double the dosing interval. Nafcillin: Metabolized by liver and largely eliminated in bile; nevertheless, dose modifications are suggested only for combined hepatic and renal failure. : Dose reduction for hepatic failure only when accompanied by renal failure. Ribavirin: AUC is unchanged wih severe hepatic failure. Rifampin: Induces hepatic enzymes responsible for inactivating methadone, cortico steroids, oral anti-diabetic agents, digitalis, quinidine, cyclosporine, oral anticoagulants, estrogens, oral contraceptives, and chloramphenicol.

Title: 2004 Pocket Book of Infectious Disease Therapy, 12th Edition Copyright ©2004 Lippincott Williams & Wilkins > Table of Content s > An timicrobial Agents > Us e of Ant imic robial Agents in Hepa tic Disease Use of Antimicrobial Agents in Hepatic Disease Many antimicrobial agents are metabolized by the liver and/or excreted via the biliary tract. Nevertheless, few require dose modifications in hepatic disease; with few exceptions, doses are usually modified only if there is concurrent renal failure and/or the liver disease is either acute or is associated with severe hepatic failure as indicated by ascites or jaundice.

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2004 Pocket Book of Infectious Disease Therapy by John G. Bartlett


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